The National Institute for Health and Clinical Excellence (NICE) has updated its draft guidance on the use of dasatinib (Sprycel,made by Bristol Myers-Squibb) and nilotinib (Tasigna,made by Novartis) for chronic myeloidleukaemia.
Following the previous public consultation and subsequent independent Appraisal Committee meeting on 13 January 2010, both NICE and the appraisal committee agreed to split the appraisal of dasatinib and nilotinib for chronic myeloid leukaemia into two separate appraisals.
To effectively appraise a new treatment, the Committee compares it to an existing one. In this case, high dose imatinib (glivec, 600 mg or 800 mg per day) has been identified as a comparator for dasatinib and nilotinib for people who are 'resistant' to imatinib (standard treatment with imatinib (400 mg per day) has stopped working), although it clearly cannot be a comparator for people who cannot tolerate imatinib.
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